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Merck
CN

SML3515

Bulevirtide trifluoroacetate

≥98% (HPLC)

Synonym(s):

Myrcludex B trifluoroacetate, Myrcludex-B trifluoroacetate, N-Tetradecanoylglycyl-Thr-Asn-Leu-Ser-Val-Pro-Asn-Pro-Leu-Gly-Phe-Phe-Pro-Asp-His-Gln-Leu-Asp-Pro-Ala-Phe-Gly-Ala-Asn-Ser-Asn-Asn-Pro-Asp-Trp-Asp-Phe-Asn-Pro-Asn-Lys-Asp-His-Trp-Pro-Glu-Ala-Asn-Lys-Val-Gly-NH2 trifluoroacetate

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About This Item

Empirical Formula (Hill Notation):
C248H355N65O72 · xC2HF3O2
Molecular Weight:
5398.86 (free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200

Key Documents

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assay

≥98% (HPLC)

form

(Powder or Lyophilized powder or film)

storage condition

desiccated

color

white to off-white

storage temp.

-10 to -25°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Bulevirtide is a synthetic lipopeptide derived from the preS1 domain of the Hepatitis B virus (HBV) envelope protein that specifically binds to hepatocytes and efficiently blocks de novo HBV and its satellite virus hepatitis D (HDV) infection both in vitro and in vivo.
HDV and HBV virion entry inhibitor

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
0000500084
0000500083
0000500084
0000500083
0000414886

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Hepatitis D virus in 2021: virology, immunology and new treatment approaches for a difficult-to-treat disease
Urban S, Neumann-Haefelin C, Lampertico P
Gut, 70, 1782-1794 (2021)
Bulevirtide for HBV and HDV infections
Yardeni D, Koh C
Drugs Today (Barc), 57(7), 433-448 (2021)
The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus.
Journal of Hepatology, 58(5), 861-867 (2013)

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