SML3516
EN106
≥98% (HPLC)
Synonym(s):
2-Chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)acetamide
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About This Item
Empirical Formula (Hill Notation):
C13H13ClN2O3
CAS Number:
Molecular Weight:
280.71
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Product Name
EN106, ≥98% (HPLC)
InChI key
GLDJSVHDOXCYPT-UHFFFAOYSA-N
SMILES string
O=C(CCl)N(C1=CC2=C(OCCO2)C=C1)CCC#N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
Cell-permeable covalent recruiter of CUL2 E3 ligase FEM1B that binds to C186 of FEM1B
EN106 is a cell-permeable covalent recruiter of CUL2 E3 ligase FEM1B that binds to C186 of FEM1B. EN106 disrupts FEM1B interactions with the FNIP1 degron and inhibits CUL2FEM1B-dependent ubiquitylation without detectable off-target effects. A modified EN106 bifunctional analog (PROTAC) recruits FEM1B and induces targeted BRD4 and BCR-ABL/c-ABL degradation.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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