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SML3516

EN106

≥98% (HPLC)

Synonym(s):

2-Chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)acetamide

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About This Item

Empirical Formula (Hill Notation):
C13H13ClN2O3
CAS Number:
757192-67-9
Molecular Weight:
280.71
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD06340076
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(CCl)N(C1=CC2=C(OCCO2)C=C1)CCC#N

InChI key

GLDJSVHDOXCYPT-UHFFFAOYSA-N

Biochem/physiol Actions

Cell-permeable covalent recruiter of CUL2 E3 ligase FEM1B that binds to C186 of FEM1B
EN106 is a cell-permeable covalent recruiter of CUL2 E3 ligase FEM1B that binds to C186 of FEM1B. EN106 disrupts FEM1B interactions with the FNIP1 degron and inhibits CUL2FEM1B-dependent ubiquitylation without detectable off-target effects. A modified EN106 bifunctional analog (PROTAC) recruits FEM1B and induces targeted BRD4 and BCR-ABL/c-ABL degradation.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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