SML3524
EtDO-P4
≥95% (HPLC)
别名:
D-EtDO-P4, D-threo-1-(3′,4′-Ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol, Ethylenedioxy-P4, N-[(1R,2R)-2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]hexadecanamide
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关于此项目
Assay:
≥95% (HPLC)
Form:
powder
Quality Segment
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
N3(CCCC3)C[C@@H](NC(=O)CCCCCCCCCCCCCCC)[C@H](O)c1cc2c(cc1)OCCO2
InChI
1S/C31H52N2O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17-30(34)32-27(25-33-20-15-16-21-33)31(35)26-18-19-28-29(24-26)37-23-22-36-28/h18-19,24,27,31,35H,2-17,20-23,25H2,1H3,(H,32,34)/t27-,31-/m1/s1
InChI key
BBTZZVJOQCCAOR-DLFZDVPBSA-N
Biochem/physiol Actions
Cell penetrant, potent and selective nanomolar inhibitor of UDP-glucose ceramide glucosyltransferase (UGCG)
EtDO-P4, a ceramide analog, is a cell penetrant, potent and selective nanomolar inhibitor of UDP-glucose ceramide glucosyltransferase (UGCG). Inhibition of UGCG by EtDO-P4 decreases drug resistance and enhances cytotoxicity of chemotherapeutic drugs such as vincristine, daunorubicin, Lucena-1 and cisplatin.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable