SML3548
8RK64
≥98% (HPLC)
Synonym(s):
(S)-N-(5-(2-azidoacetyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)-1-cyanopyrrolidine-3-carboxamide
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About This Item
Empirical Formula (Hill Notation):
C14H16N8O2S
CAS Number:
Molecular Weight:
360.39
UNSPSC Code:
41121800
NACRES:
NA.21
InChI key
KIWKRCCIHSGWQS-VIFPVBQESA-N
SMILES string
O=C([C@H]1CCN(C#N)C1)NC2=NC3=C(S2)CN(C(CN=[N+]=[N-])=O)CC3
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
8RK64 is a cell penetrant, potent and selective covalent inhibitor of UCHL1 (ubiquitin carboxy-terminal hydrolase L1) that binds to the active-site cysteine residue of UCHL1. 8RK64 potently inhibits UCHL1 activity in cells.
Cell penetrant, potent and selective covalent inhibitor of UCHL1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Raymond Kooij et al.
Journal of the American Chemical Society, 142(39), 16825-16841 (2020-09-05)
Many reagents have emerged to study the function of specific enzymes in vitro. On the other hand, target specific reagents are scarce or need improvement, allowing investigations of the function of individual enzymes in their native cellular context. Here we
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