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SML3553

STF-1084

Name: STF-1084
Brand: SIGMA

≥98% (HPLC), ENPP1 inhibitor, powder

Synonym(s):

ENPP1 inhibitor Compound 15, P-[2-[1-(6,7-dimethoxy-4-quinazolinyl)-4-piperidinyl]ethyl]-phosphonic acid

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₂₄N₃O₅P

CAS Number:

2298390-71-1

Molecular Weight:

381.36

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Product Name

STF-1084, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=P(O)(O)CCC(CC1)CCN1C2=NC=NC3=C2C=C(OC)C(OC)=C3

InChI

1S/C17H24N3O5P/c1-24-15-9-13-14(10-16(15)25-2)18-11-19-17(13)20-6-3-12(4-7-20)5-8-26(21,22)23/h9-12H,3-8H2,1-2H3,(H2,21,22,23)

InChI key

SNLWMWQNJTVWKD-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Biochem/physiol Actions

Cell-impermeable, potent, selective, stable and nontoxic competitive inhibitor of ENPP1 that inhibit degradation of extracellular cGAMP under physiological conditions

STF-1084 (ENPP1 inhibitor Compound 15) Is a cell-impermeable, potent, selective, stable and nontoxic competitive inhibitor of ENPP1 (ectonucleotide pyrophosphatase phosphodiesterase 1) that inhibit degradation of extracellular cGAMP under physiological conditions. STF-1084 had no effect on intracellular cGAMP. STF-1084 synergized with IR to significantly delay tumor progression in three triple-negative breast cancer cell lines 4T1-luc mice model.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000448694

0000354471

0000409735

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32726585

Cell Chemical Biology, 27, 1347-1358 (2020)

Extracellular cGAMP is a cancer cell-produced immunotransmitter involved in radiation-induced anti-cancer immunity

Nature cancer, 1, 184-196 (2020)

Global Trade Item Number

SKU	GTIN
SML3553-25MG	04065268039656
SML3553-5MG	04065268039663

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