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Merck
CN

SML3555

Pirmenol

≥98% (HPLC)

Synonym(s):

CL-845, cis-(±)-α-[3-(2,6-Dimethyl-1-piperidinyl)propyl]-α-phenyl-2-pyridinemethanol, rel-α-​[3-​[(2R,​6S)​-​2,​6-Ddimethyl-​1-​piperidinyl]​propyl]​-​α-​phenyl-​2-​pyridinemethanol

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About This Item

Empirical Formula (Hill Notation):
C22H30N2O
CAS Number:
68252-19-7
Molecular Weight:
338.49
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD01758678

Key Documents

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InChI

1S/C22H30N2O/c1-18-10-8-11-19(2)24(18)17-9-15-22(25,20-12-4-3-5-13-20)21-14-6-7-16-23-21/h3-7,12-14,16,18-19,25H,8-11,15,17H2,1-2H3/t18-,19+,22?

SMILES string

OC(C1=CC=CC=C1)(C2=NC=CC=C2)CCCN3[C@@H](C)CCC[C@H]3C

InChI key

APUDBKTWDCXQJA-QIDMFYOTSA-N

assay

≥98% (HPLC)

form

powder

color

, White to v. dark grey

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Antiarrhythmic agent class Ia
Pirmenol is an antiarrhythmic agent class Ia that exhibit long half-life and low toxicities. Pirmenol suppresses premature ventricular contractions in human studies.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000205354
0000205355
0000198226
0000198226
0000205354

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Pirmenol inhibits muscarinic acetylcholine receptor-operated K+ current in the guinea pig heart.
Watanabe Y, Hara Y, Tamagawa M, Nakaya H.
European Journal of Pharmacology (1997)
CL-845 (pirmenol hydrochloride): a new orally effective long-acting antiarrhythmic agent
Steffe TJ, Mertz TE, Hastings SG, Potoczak RE, Kaplan HR.
Journal of Pharmacology and Experimental Therapeutics (1980)
Pirmenol: an antiarrhythmic drug with unique electrocardiographic features--a double-blind placebo-controlled comparison with quinidine
Salerno DM, Fifield J, Farmer C, Hodges M.
Clinical Cardiology (1991)

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