SML3556
Compound 18
≥98% (HPLC)
Synonym(s):
MPO-IN-28, N-(7-Methoxy-4-methyl-2-quinazolinyl)guanidine
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About This Item
Empirical Formula (Hill Notation):
C11H13N5O
CAS Number:
Molecular Weight:
231.25
UNSPSC Code:
51111800
NACRES:
NA.77
SMILES string
N(c1nc2c(c(n1)C)ccc(c2)OC)\C(=N\[H])\N
InChI key
ZJBMSSBTCGJZEE-UHFFFAOYSA-N
InChI
1S/C11H13N5O/c1-6-8-4-3-7(17-2)5-9(8)15-11(14-6)16-10(12)13/h3-5H,1-2H3,(H4,12,13,14,15,16)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
-10 to -25°C
Quality Level
Related Categories
Biochem/physiol Actions
Agonist of Aedes aegypti mosquitoes NPY-like receptor 7 (NPYLR7) that inhibit mosquito attraction to humans; potent inhibitor of myeloperoxidase (MPO)
Compound 18 is an agonist of Aedes aegypti mosquitoes NPY-like receptor 7 (NPYLR7) that inhibit mosquito attraction to humans and other hosts. Compound 18 suppresses biting and blood-feeding on a live host. Also, It (MPO-IN-28) is a potent myeloperoxidase (MPO) inhibitor with an IC50 of 44 nM.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Laura B Duvall et al.
Cell, 176(4), 687-701 (2019-02-09)
Female Aedes aegypti mosquitoes bite humans to obtain blood to develop their eggs. Remarkably, their strong attraction to humans is suppressed for days after the blood meal by an unknown mechanism. We investigated a role for neuropeptide Y (NPY)-related signaling
Jalal Soubhye et al.
Journal of medicinal chemistry, 60(15), 6563-6586 (2017-07-04)
The heme enzyme myeloperoxidase (MPO) participates in innate immune defense mechanism through formation of microbicidal reactive oxidants. However, evidence has emerged that MPO-derived oxidants contribute to propagation of inflammatory diseases. Because of the deleterious effects of circulating MPO, there is
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