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Merck
CN

SML3566

SUN11602

≥95% (HPLC)

Synonym(s):

4-[[4-[[2-(4-Amino-2,3,5,6-tetramethylanilino)acetyl]-methylamino]piperidin-1-yl]methyl]benzamide, 4-[[4-[[2-[(4-Amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]benzamide, SUN 11602, SUN-11602

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About This Item

Empirical Formula (Hill Notation):
C26H37N5O2
CAS Number:
704869-38-5
Molecular Weight:
451.60
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD28133375

Key Documents

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SMILES string

N2(CCC(CC2)N(C)C(=O)CNc3c(c(c(c(c3C)C)N)C)C)Cc1ccc(cc1)C(=O)N

InChI

1S/C26H37N5O2/c1-16-18(3)25(19(4)17(2)24(16)27)29-14-23(32)30(5)22-10-12-31(13-11-22)15-20-6-8-21(9-7-20)26(28)33/h6-9,22,29H,10-15,27H2,1-5H3,(H2,28,33)

InChI key

KCODNOOPOPTZMO-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Orally active basic fibroblast growth factor (bFGF, FGF2) mimetic with neuroprotective efficacy in vitro and in vivo.
SUN11602 is an orally active basic fibroblast growth factor (bFGF, FGF2) mimetic that protects against glutamate toxicity in primary rat cerebrocortical neuron (0.1-1 μM SUN11602; 150 μM glutamate) and murine hippocampal neuron cultures (0.3-3 μM SUN11602; 100 μM glutamate). When administered in vivo, SUN11602 exhibits therapeutic efficacy in a rat hippocampal-lesion model (1-10 mg/kg p.o. 24h post Aβ1-40 injection) and a murine MPTP-induced nigrostriatal degeneration model (2.5-5 mg/kg/day p.o.).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000230583
0000230582
0000230582
0000230583

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Ryoko Ogino et al.
Brain research, 1585, 159-166 (2014-08-19)
Basic fibroblast growth factor (bFGF/FGF-2) is known to possess neuroprotective and neurite outgrowth activity properties. In this study, the effects of a novel synthetic compound that mimics the neuroprotective properties of bFGF - SUN11602 - were examined in vitro and
Norihito Murayama et al.
Brain research, 1594, 71-81 (2014-12-03)
Basic fibroblast growth factor (FGF-2/bFGF) possesses neuroprotective activity and promotes cell proliferation. In this study, the novel synthetic compound 4-({4-[[(4-amino-2,3,5,6-tetramethylanilino)acetyl](methyl)amino]-1-piperidinyl}methyl)benzamide (SUN11602) exhibited neuroprotective activities similar to those of FGF-2 without promoting cell proliferation. In primary cultures of hippocampal neurons, stimulation
SUN11602, a bFGF mimetic, modulated neuroinflammation, apoptosis and calcium-binding proteins in an in vivo model of MPTP-induced nigrostriatal degeneration
Journal of Neuroinflammation, 19(1), 107-107 (2022)
Cintia D S Horinouchi et al.
Archiv der Pharmazie, 354(8), e2100082-e2100082 (2021-05-09)
Small molecules have gained considerable interest in regenerative medicine, as they can effectively modulate cell fates in a spatiotemporal controllable fashion. A continuous challenge in the field represents genuine mimicry or activation of growth factor signaling with small molecules. Here
Baojiang Chen et al.
Bioengineered, 13(1), 1530-1540 (2022-01-11)
Psoriasis is a common chronic immune-mediated disease that often has a serious negative impact on the physical and mental health of patients. Dihydroartemisinin (DHA) is a drug with anti-fibrotic and anti-inflammatory effects that may be involved in the autoimmune regulation
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