SML3567
EN450
≥98% (HPLC)
Synonym(s):
N-(2-Chloro-5-(N,N-dimethylsulfamoyl)phenyl)acrylamide
Sign Into View Organizational & Contract Pricing
Select a Size
About This Item
Empirical Formula (Hill Notation):
C11H13ClN2O3S
CAS Number:
Molecular Weight:
288.75
UNSPSC Code:
12352200
NACRES:
NA.21
Quality Level
Assay
≥98% (HPLC)
form
powder
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(NC1=CC(S(=O)(N(C)C)=O)=CC=C1Cl)C=C
InChI key
OXFXDOLAQBMOPH-UHFFFAOYSA-N
Related Categories
Biochem/physiol Actions
Cysteine reactive UBE2D/NFKB1 molecular glue degrader; NFKB1 molecular glue degrader
EN450 is a molecular glue degraders of the oncogenic transcription factor NFKB1 that induces ternary complex formation between ubiquitin-conjugating enzyme E2D1 (UBE2D1) and NFKB1. EN450 covalently modifies an allosteric C111 in UBE2D1 and significantly reduces NFKB1 p105 levels. It impairs leukemia cell viability in a NEDDylation and proteasome-dependent manner at 50 µM.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
Don't see the Right Version?
If you require a particular version, you can look up a specific certificate by the Lot or Batch number.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Chemoproteomics-Enabled Discovery of a Covalent Molecular Glue Degrader Targeting NF-?B
bioRxiv : the preprint server for biology (2022)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service