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Merck
CN

SML3571

GS-621763

≥98% (HPLC)

Synonym(s):

(2R,3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-cyano-5-((isobutyryloxy)methyl)tetrahydrofuran-3,4-diyl bis(2-methylpropanoate)

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About This Item

Empirical Formula (Hill Notation):
C24H31N5O7
CAS Number:
2647442-13-3
Molecular Weight:
501.53
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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InChI

1S/C24H31N5O7/c1-12(2)21(30)33-9-16-18(34-22(31)13(3)4)19(35-23(32)14(5)6)24(10-25,36-16)17-8-7-15-20(26)27-11-28-29(15)17/h7-8,11-14,16,18-19H,9H2,1-6H3,(H2,26,27,28)/t16-,18-,19-,24+/m1/s1

InChI key

RVSSLHFYCSUAHY-JQGROFRJSA-N

SMILES string

N#C[C@@]1(C2=CC=C3C(N)=NC=NN32)O[C@@H]([C@H]([C@H]1OC(C(C)C)=O)OC(C(C)C)=O)COC(C(C)C)=O

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

GS-621763 is an orally bioavailable analog of remdesivir, which is efficiently converted in plasma to active metabolite GS-441524, or in lungs to the bioactive triphosphate GS-443902. GS-621763 effectively reduces SARS-CoV-2 burden to near-undetectable levels in ferrets.
Orally bioavailable analog of remdesivir, which is efficiently converted in plasma to active metabolite GS-441524

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000220594
0000220595
0000210369
0000210369
0000220595

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Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets
Nature Communications, 12, 6415-6415 (2021)
Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine C-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV
Journal of Medicinal Chemistry, 64, 5001-5017 (2021)
Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice
Science Translational Medicine, 14 (2022)

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