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Merck
CN

SML3581

NVP-ACQ090

≥98% (HPLC)

Synonym(s):

1-[[(4S,4aS,8aR)-Decahydro-2-[(2S)-3-(6-methoxy-3-pyridinyl)-2-methylpropyl]-4-isoquinolinyl]carbonyl]-4-(3,4-difluorophenyl)-piperazine, ACQ 090, ACQ-090, ACQ090, [(4S,4aS,8aR)-Decahydro-2-[(2S)-3-(6-methoxy-3-pyridinyl)-2-methylpropyl]-4-isoquinolinyl][4-(3,4-difluorophenyl)-1-piperazinyl]methanone, [4-(3,4-Difluoro-phenyl)-piperazine-1-yl]-{(4S,4aS,8aR)-2[(S)-3-(6-methoxy-pyridin-3-yl)-2-methyl-propyl]-decahydroisoquinoline-4-yl}-methanone

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About This Item

Empirical Formula (Hill Notation):
C30H40F2N4O2
CAS Number:
362612-47-3
Molecular Weight:
526.66
NACRES:
NA.77
UNSPSC Code:
51111800

Key Documents

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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

NVP-ACQ090 is a non-peptidic, potent and subtype-selective somatostatin (SRIF; somatotropin release-inhibiting factor) receptor (SST3; SSTR3) antagonist (hSST3 pKD = 8.15, hSSTR1/2/4/5 pKD = 5.69/5.34/5.83/5.95). NVP-ACQ090 blocks hSST3 phosphorylation induced by somatostatin-14 (SS-14) in cultures and impaires object recognition in wild-type mice in vivo (50 μg/kg i.p.).
Non-peptidic, potent and subtype-selective somatostatin (SRIF; somatotropin release-inhibiting factor) receptor (SST3; SSTR3) antagonist in vitro and in vivo

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Decahydroisoquinoline derivatives as novel non-peptidic, potent and subtype-selective somatostatin sst(3) receptor antagonists
Bioorganic & Medicinal Chemistry Letters, 20(5), 1728-1734 (2010)
Andreas Lehmann et al.
Molecular endocrinology (Baltimore, Md.), 30(6), 645-659 (2016-04-22)
The human somatostatin receptor 3 (sst3) is expressed in about 50% of all neuroendocrine tumors and hence a promising target for multireceptor somatostatin analogs. The sst3 receptor is unique among ssts in that it exhibits a very long intracellular C-terminal
Emily B Einstein et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(12), 4306-4314 (2010-03-26)
Most neurons possess a single, nonmotile cilium that projects out from the cell surface. These microtubule-based organelles are important in brain development and neurogenesis; however, their function in mature neurons is unknown. Cilia express a complement of proteins distinct from

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