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About This Item
Empirical Formula (Hill Notation):
C25H36F3N5O3 · C4H6O4
CAS Number:
Molecular Weight:
629.67
MDL number:
UNSPSC Code:
51111800
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
room temp
SMILES string
CO[C@H]1[C@@H](N[C@@H]2CC[C@@](C(N3C[C@@]4([H])N(C5=NC=NC(C(F)(F)F)=C5)C[C@]3([H])C4)=O)(C(C)C)C2)CCOC1
InChI key
MCRWZBYTLVCCJJ-DKALBXGISA-N
Biochem/physiol Actions
Orally available, potent and selective CCR2/5 receptor antagonist
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Frontiers in Molecular Neuroscience, 15, 751044-751044 (2022)
Effect of PF-04634817, an Oral CCR2/5 Chemokine Receptor Antagonist, on Albuminuria in Adults with Overt Diabetic Nephropathy
Gale JD, Gilbert S, Blumenthal S, Elliott T, Pergola PE, Goteti K, Scheele W, Perros-Huguet C
Kidney international reports, 3, 1316-1327 (2018)
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