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SML3586

MU1700 dihydrochloride

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≥98% (HPLC)

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Synonym(s):
6-(4-(Piperazin-1-yl)phenyl)-3-(quinolin-4-yl)furo[3,2-b]pyridine dihydrochloride
Empirical Formula (Hill Notation):
C26H22N4O ·2HCl
Molecular Weight:
479.40

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

2-8°C

Biochem/physiol Actions

MU1700 is a potent and selective TGF-β type I receptors ALK1/ACVRL1 & ALK2/ACVR1 inhibitor (IC50 = 13/6 nM, [ATP] = 10 mM) that inhibits ALK6/BMPR1B only at higher concentrations (IC50 = 41 nM) with good kinome selectivity over >360 other kinases, including ALK3/BMPR1A (IC50 = 425 nM), ALK4/ACVR1B & ALK5/TGFBR1 (inactive). MU1700 inhibits cellular phospho-SMAD1/5/8 induction by 10 ng/mL BMP-7 and phospho-SMAD2 induction by either 10 ng/mL activin A or 100 ng/mL TGF-β1 with good target selectivity by cellular NanoBRET assays (ALK1/2 IC50 = 225/27 nM).

Caution

Hygroscopic

Regulatory Information

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