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Merck
CN

SML3588

J147

≥98% (HPLC)

Synonym(s):

(E)-N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N′-(3-methoxybenzylidene)acetohydrazide, 2,2,2-Trifluoro-acetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide, J 147

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About This Item

Empirical Formula (Hill Notation):
C18H17F3N2O2
CAS Number:
1807913-16-1
Molecular Weight:
350.33
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD25976644

Key Documents

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InChI

1S/C18H17F3N2O2/c1-12-7-8-16(13(2)9-12)23(17(24)18(19,20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H,1-3H3/b22-11+

InChI key

HYMZAYGFKNNHDN-SSDVNMTOSA-N

SMILES string

COC1=CC(/C=N/N(C2=C(C=C(C=C2)C)C)C(C(F)(F)F)=O)=CC=C1

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Broadly neuroprotective agent that enhances the memory in normal and Alzheimer’s disease (AD) transgenic mice
J147 is a broadly neuroprotective (in multiple assays) compound that enhances the memory in normal and Alzheimer’s disease (AD) transgenic mice. J147 has neurotrophic and BDNF-like activities that are independent of the BDNF receptor, and TrkB. Also it appears that J147 has a small but significant effect on Ab metabolism by reducing Ab1–42 in the soluble fraction of the hippocampus.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000220807
0000220806
0000212935
0000212935
0000220807

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A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease
Chen Q
PLoS ONE, 6(12) (2011)

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