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SML3589

ITD-1

≥98% (HPLC)

Synonym(s):

4-[1,1′-Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester, Inducer of type II TGF-b receptor (TGFBR2) degradation-1

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About This Item

Empirical Formula (Hill Notation):
C27H29NO3
CAS Number:
1099644-42-4
Molecular Weight:
415.52
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD28133391
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

2-8°C

SMILES string

O=C(CC(C)(C)C1)C2=C1NC(C)=C(C(OCC)=O)C2C(C=C3)=CC=C3C4=CC=CC=C4

InChI

1S/C27H29NO3/c1-5-31-26(30)23-17(2)28-21-15-27(3,4)16-22(29)25(21)24(23)20-13-11-19(12-14-20)18-9-7-6-8-10-18/h6-14,24,28H,5,15-16H2,1-4H3

InChI key

ULFUJLFTRWWLPO-UHFFFAOYSA-N

Biochem/physiol Actions

ITD-1 is a selective TGF-ß pathway inhibitor that induces selective proteasomal degradation of type II TGF-b receptor (TGFBR2). ITD-1 stimulates embryonic stem cells to differentiate into cardiomyocytes.
Selective TGF-ß pathway inhibitor; stimulates ESC differentiation into cardiomyocytes

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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