SML3608
Massonianoside B
≥95% (HPLC)
Synonym(s):
4-[(2S,3R)-2,3-Dihydro-7-hydroxy-3-(hydroxymethyl)-5-(3-hydroxypropyl)-2-benzofuranyl]-2-methoxyphenyl 6-deoxy-α-L-mannopyranoside
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About This Item
Empirical Formula (Hill Notation):
C25H32O10
CAS Number:
Molecular Weight:
492.52
UNSPSC Code:
12352200
NACRES:
NA.21
MDL number:
Quality Level
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Related Categories
Biochem/physiol Actions
Cell-permeable, potent, highly selective, reversible and SAM-competitive DOT1L inhibitor
Massonianoside B is a cell-permeable, potent, highly selective, reversible and SAM-competitive DOT1L (disruptor of 4 telomeric silencing 1-like) inhibitor that decreases cellular levels of H3K79 methylation and inhibits the MLL fusion target genes HOXA9 and MEIS1 expression. Massonianoside B exhibits anti-leukemic activity. It is metabolically stable in both human and mouse liver microsomes.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Jie Chen et al.
ACS chemical biology, 14(5), 873-881 (2019-04-06)
Protein methyltransferases (PMTs) are involved in numerous biological processes and have been studied as a promising target class in the field of oncology and other diseases. Disruptor of telomeric silencing 1-like (DOT1L), a histone H3 lysine 79 (H3K79) methyltransferase, plays
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML3608-5MG | 04065269326601 |
| SML3608-25MG | 04065269326588 |
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