SML3608
Massonianoside B
≥95% (HPLC)
Synonym(s):
4-[(2S,3R)-2,3-Dihydro-7-hydroxy-3-(hydroxymethyl)-5-(3-hydroxypropyl)-2-benzofuranyl]-2-methoxyphenyl 6-deoxy-α-L-mannopyranoside
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About This Item
Empirical Formula (Hill Notation):
C25H32O10
CAS Number:
Molecular Weight:
492.52
UNSPSC Code:
12352200
NACRES:
NA.21
MDL number:
Assay:
≥95% (HPLC)
Form:
powder
Quality Segment
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Cell-permeable, potent, highly selective, reversible and SAM-competitive DOT1L inhibitor
Massonianoside B is a cell-permeable, potent, highly selective, reversible and SAM-competitive DOT1L (disruptor of 4 telomeric silencing 1-like) inhibitor that decreases cellular levels of H3K79 methylation and inhibits the MLL fusion target genes HOXA9 and MEIS1 expression. Massonianoside B exhibits anti-leukemic activity. It is metabolically stable in both human and mouse liver microsomes.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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