SML3623
DSRM-3716
≥98% (HPLC)
Synonym(s):
5-Iodoisoquinoline, DSRM 3716, DSRM3716
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About This Item
Empirical Formula (Hill Notation):
C9H6IN
CAS Number:
Molecular Weight:
255.06
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
, yellow to light brown
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
SMILES string
Ic1c2c(cncc2)ccc1
InChI key
CUILFTFMBBGSFT-UHFFFAOYSA-N
Biochem/physiol Actions
DSRM-3716 is a potent and selective SARM1 NADase inhibitor (NAD+ hydrolysis IC50 = 75 nM using recombinant SARM1 SAM-TIR construct) that recapitulates the SARM1-/- phenotype and protects axons from degeneration induced by axotomy (EC50 = 2.1/1.9 µM by fragmentation/NfL release using mouse DRG neurons; 81/88% protection by 1/3 µM DSRM-3716 using human iPSC-derived motor neurons) or mitochondrial dysfunction (3-30 µM DSRM-3716 against 25 µM rotenone-induced injury; mouse DRG neurons). Mechanistically, DSRM-3716 undergoes base exchange with the nicotinamide (NAM) moiety of nicotinamide adenine dinucleotide (NAD+) to yield the bona fide inhibitor 1AD.
Potent and selective SARM1 NADase inhibitor that protects axons from degeneration induced by axotomy or mitochondrial dysfunction.
Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Skin Irrit. 2
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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