SML3633
C23.28-TPP
≥98% (HPLC)
Synonym(s):
(6-(4-(2,5-Dimethylphenyl)-4-oxobutanoyloxy)hexyl)triphenylphosphonium bromide
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About This Item
Empirical Formula (Hill Notation):
C36H40O3P·Br
CAS Number:
Molecular Weight:
631.58
NACRES:
NA.21
UNSPSC Code:
12352200
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Related Categories
Biochem/physiol Actions
Bacteria-permeable prodrug inhibitor of IspH
C23.28-TPP is a bacteria-permeable prodrug inhibitor of IspH that is bactericidal to number of multidrug-resistant bacteria including Acinetobacter, Pseudomonas, Klebsiella, Enterobacter, Vibrio, Shigella, Salmonella, Yersinia, Mycobacterium and Bacillus. It stimulates rapid immune response through activation human Vγ9Vδ2 T cells in a humanized mouse model of bacterial infection. C23.28-TPP was able to clear infection by a clinically isolated multidrug-resistant strain of E. aerogenes (UCI 15) in BALBc mice. It is relatively non-toxic to mammalian cells.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Kumar Sachin Singh et al.
Nature, 589(7843), 597-602 (2020-12-29)
Isoprenoids are vital for all organisms, in which they maintain membrane stability and support core functions such as respiration1. IspH, an enzyme in the methyl erythritol phosphate pathway of isoprenoid synthesis, is essential for Gram-negative bacteria, mycobacteria and apicomplexans2,3. Its
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML3633-5MG | 04065270565716 |
| SML3633-25MG | 04065270565105 |
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