SML3633
C23.28-TPP
≥98% (HPLC)
Synonym(s):
(6-(4-(2,5-Dimethylphenyl)-4-oxobutanoyloxy)hexyl)triphenylphosphonium bromide
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About This Item
Empirical Formula (Hill Notation):
C36H40O3P·Br
CAS Number:
Molecular Weight:
631.58
NACRES:
NA.21
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
Bacteria-permeable prodrug inhibitor of IspH
C23.28-TPP is a bacteria-permeable prodrug inhibitor of IspH that is bactericidal to number of multidrug-resistant bacteria including Acinetobacter, Pseudomonas, Klebsiella, Enterobacter, Vibrio, Shigella, Salmonella, Yersinia, Mycobacterium and Bacillus. It stimulates rapid immune response through activation human Vγ9Vδ2 T cells in a humanized mouse model of bacterial infection. C23.28-TPP was able to clear infection by a clinically isolated multidrug-resistant strain of E. aerogenes (UCI 15) in BALBc mice. It is relatively non-toxic to mammalian cells.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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