SML3634
TRULI
≥98% (HPLC), YAP signaling activator, powder
Synonym(s):
N-(3-Benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
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About This Item
Empirical Formula (Hill Notation):
C18H14N4OS
CAS Number:
Molecular Weight:
334.39
UNSPSC Code:
12352200
NACRES:
NA.77
Product Name
TRULI, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(C1=CNC2=C1C=CC=N2)N=C3SC=CN3CC4=CC=CC=C4
InChI
1S/C18H14N4OS/c23-17(15-11-20-16-14(15)7-4-8-19-16)21-18-22(9-10-24-18)12-13-5-2-1-3-6-13/h1-11H,12H2,(H,19,20)
InChI key
VTXBMVZVPUSAJF-UHFFFAOYSA-N
Related Categories
Biochem/physiol Actions
Cell penetrant, potent and non-toxic activator of Yap signaling; inhibitor of Lats kinases
TRULI is a call penetrant, potent and non-toxic activator of Yap signaling. TRULI is an ATP-competitive inhibitor of Lats kinases (the core enzymes in Hippo signaling) that induces robust Yap nuclear translocation and prevents Yap phosphorylation. TRULI induces proliferation of supporting cells in the murine inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Nathaniel Kastan et al.
Nature communications, 12(1), 3100-3100 (2021-05-27)
Hippo signaling is an evolutionarily conserved pathway that restricts growth and regeneration predominantly by suppressing the activity of the transcriptional coactivator Yap. Using a high-throughput phenotypic screen, we identified a potent and non-toxic activator of Yap. In vitro kinase assays
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML3634-5MG | 04065269782001 |
| SML3634-25MG | 04065269781998 |
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