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Merck
CN

SML3642

PD 173955

≥98% (HPLC)

Synonym(s):

6-(2,6-Dichlorophenyl)-8-methyl-2-[[3-(methylthio)phenyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one, PD-173955

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About This Item

Empirical Formula (Hill Notation):
C21H16Cl2N4OS
CAS Number:
260415-63-2
Molecular Weight:
443.35
UNSPSC Code:
12352200
NACRES:
NA.25
MDL number:
MFCD16038305

Key Documents

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SMILES string

S(C)c1cc(ccc1)Nc2nc3c(cn2)C=C(C(=O)N3C)c4c(cccc4Cl)Cl

InChI

1S/C21H16Cl2N4OS/c1-27-19-12(9-15(20(27)28)18-16(22)7-4-8-17(18)23)11-24-21(26-19)25-13-5-3-6-14(10-13)29-2/h3-11H,1-2H3,(H,24,25,26)

InChI key

VAARYSWULJUGST-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

-10 to -25°C

Quality Level

100

Related Categories

Biochem/physiol Actions

PD 173955 is Tyrosine kinase inhibitor (TKI), which potently inhibits Bcr-Abl (IC50 = 1-2 nM), Src family kinase inhibitor specific for Src and Yes kinases (IC50 of 22 nM), and MAPK6/ERK3. According to IUPHAR/BPS Guide to PHARMACOLOGY PD 173955 is a best standard MAPK6 inhibitor pKD = 6.8
Tyrosine kinase type I inhibitor; potently inhibits Bcr-Abl and MAPK6/ERK3; Src family kinase inhibitor specific for Src and Yes kinases

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000238278
0000238279
0000238279
0000238278

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Anjana Sinha et al.
ACS medicinal chemistry letters, 10(10), 1430-1435 (2019-10-18)
Compound 3a, DV2-103, is a kinase inactive analogue of a potent Abl1/Src kinase inhibitor, PD173955, 2. Both compounds, 2 and 3a, are known to reduce production of beta amyloid (Aβ) peptide in cells and animal models. We have now prepared
Arjun Kumar Kalimuthu et al.
Scientific reports, 11(1), 21488-21488 (2021-11-04)
Spice-rich recipes are referred to as "functional foods" because they include a variety of bioactive chemicals that have health-promoting properties, in addition to their nutritional value. Using pharmacoinformatics-based analysis, we explored the relevance of bioactive chemicals found in Rasam (a

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