SML3642
PD 173955
≥98% (HPLC)
Synonym(s):
6-(2,6-Dichlorophenyl)-8-methyl-2-[[3-(methylthio)phenyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one, PD-173955
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About This Item
Empirical Formula (Hill Notation):
C21H16Cl2N4OS
CAS Number:
Molecular Weight:
443.35
UNSPSC Code:
12352200
NACRES:
NA.25
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
-10 to -25°C
SMILES string
S(C)c1cc(ccc1)Nc2nc3c(cn2)C=C(C(=O)N3C)c4c(cccc4Cl)Cl
InChI
1S/C21H16Cl2N4OS/c1-27-19-12(9-15(20(27)28)18-16(22)7-4-8-17(18)23)11-24-21(26-19)25-13-5-3-6-14(10-13)29-2/h3-11H,1-2H3,(H,24,25,26)
InChI key
VAARYSWULJUGST-UHFFFAOYSA-N
Biochem/physiol Actions
PD 173955 is Tyrosine kinase inhibitor (TKI), which potently inhibits Bcr-Abl (IC50 = 1-2 nM), Src family kinase inhibitor specific for Src and Yes kinases (IC50 of 22 nM), and MAPK6/ERK3. According to IUPHAR/BPS Guide to PHARMACOLOGY PD 173955 is a best standard MAPK6 inhibitor pKD = 6.8
Tyrosine kinase type I inhibitor; potently inhibits Bcr-Abl and MAPK6/ERK3; Src family kinase inhibitor specific for Src and Yes kinases
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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