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SML3655

LockdownPro

≥97% (HPLC)

Synonym(s):

Tetraethyl 4,4′-((propane-2,2-diylbis(4,1-phenylene))bis(oxy))diphthalate

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About This Item

Empirical Formula (Hill Notation):
C39H40O10
Molecular Weight:
668.73
UNSPSC Code:
12352200
NACRES:
NA.25
Assay:
≥97% (HPLC)
Form:
(oil or liquid)
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Quality Segment

100

assay

≥97% (HPLC)

form

(oil or liquid)

color

colorless to yellow

storage temp.

2-8°C

SMILES string

CC(C1=CC=C(C=C1)OC2=CC(C(OCC)=O)=C(C(OCC)=O)C=C2)(C3=CC=C(OC4=CC(C(OCC)=O)=C(C(OCC)=O)C=C4)C=C3)C

InChI

1S/C39H40O10/c1-7-44-35(40)31-21-19-29(23-33(31)37(42)46-9-3)48-27-15-11-25(12-16-27)39(5,6)26-13-17-28(18-14-26)49-30-20-22-32(36(41)45-8-2)34(24-30)38(43)47-10-4/h11-24H,7-10H2,1-6H3

InChI key

ROEOSYBNNXMANC-UHFFFAOYSA-N

Biochem/physiol Actions

Cell permeable, potent, and selective allosteric inhibitor of phosphatase PPM1F that inhibits tissue invasion by PPM1F-overexpressing human cancer cells
LockdownPro, an esterified lockdown analog with better cell permeability, is a cell permeable, potent, and selective allosteric inhibitor of phosphatase PPM1F. LockdownPro potently inhibits tissue invasion by PPM1F-overexpressing human cancer cells. It does not inhibit PPM1F in vitro.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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