SML3659
SJB2-043
≥98% (HPLC)
Synonym(s):
2-Phenyl-naphth[2,3-d]oxazole-4,9-dione
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About This Item
Empirical Formula (Hill Notation):
C17H9NO3
CAS Number:
Molecular Weight:
275.26
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.25
Quality Level
Assay
≥98% (HPLC)
form
powder
color
, Faint green to yellow
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
SMILES string
n1c2c([o]c1c4ccccc4)C(=O)c3c(cccc3)C2=O
InChI
1S/C17H9NO3/c19-14-11-8-4-5-9-12(11)15(20)16-13(14)18-17(21-16)10-6-2-1-3-7-10/h1-9H
InChI key
CMYQQADDUUDCCA-UHFFFAOYSA-N
Related Categories
Biochem/physiol Actions
SJB2-043 is a ubiquitin-specific protease USP1 inhibitor (IC50 = 544 nM using USP1/UAF1 complex) that exhibits anti-proliferation efficacy against chronic and acute myeloid leukemia lines (IC50 <2 µM; K562, OCI-AML3, SK-NO1, U937) and primary acute myelogenous leukemia (AML) patient-derived leukemic cells by promoting the degradation of transcription factor DNA binding 1 (ID1). SJB2-043 is also reported to be an allosteric site-targeting inhibitor against PLPro (IC50 = 0.56 μM), the papain-like cysteine protease with deubiquitination and deISGylation activities that suppress host innate immune responses toward SARS-CoV-2 infection.
Ubiquitin-specific protease USP1 inhibitor with anti-leukemia efficacy. Also reported to inhibit SARS-CoV-2 papain-like cysteine protease PLPro.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Chia-Chuan Cho et al.
ChemMedChem, 17(1), e202100455-e202100455 (2021-08-24)
As the pathogen of COVID-19, SARS-CoV-2 encodes two essential cysteine proteases that process the pathogen's two large polypeptide products pp1a and pp1ab in the human cell host to form 15 functionally important, mature nonstructural proteins. One of the two enzymes
Minyoung Noh et al.
Frontiers in pharmacology, 12, 695009-695009 (2021-06-22)
Endothelial barrier integrity is important for vascular homeostasis, and hyperpermeability participates in the progression of many pathological states, such as diabetic retinopathy, ischemic stroke, chronic bowel disease, and inflammatory disease. Here, using drug repositioning, we discovered that primaquine diphosphate (PD)
Helena Mistry et al.
Molecular cancer therapeutics, 12(12), 2651-2662 (2013-10-17)
Inhibitor of DNA binding 1 (ID1) transcription factor is essential for the proliferation and progression of many cancer types, including leukemia. However, the ID1 protein has not yet been therapeutically targeted in leukemia. ID1 is normally polyubiquitinated and degraded by
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