SML3694
FR901464
≥95% (HPLC)
Synonym(s):
(2Z,4S)-4-(acetyloxy)-N-[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methyl-2,4-pentadien-1-yl]tetrahydro-2,5-dimethyl-2H-pyran-3-yl]-2-Pentenamide, FR 901464, WB 2663B
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About This Item
Empirical Formula (Hill Notation):
C27H41NO8
CAS Number:
Molecular Weight:
507.62
NACRES:
NA.77
UNSPSC Code:
12352200
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
shipped in
dry ice
storage temp.
−70°C
Quality Level
Biochem/physiol Actions
Inhibitor of pre-mRNA splicing; potent antitumor agent.
FR901464 is a potent anticancer agent isolated from the culture broth of the bacterium Pseudomonas sp. 2663. The compound binds to the splicing factor 3b complex and inhibits pre-mRNA splicing. FR901464 causes cell cycle arrest at the G1 and G2/M phases.
FR901464 is a potent anticancer agent isolated from the culture broth of the bacterium Pseudomonas sp. 2663. The compound binds to the splicing factor 3b complex and inhibits pre-mRNA splicing. FR901464 causes cell cycle arrest at the G1 and G2/M phases.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Splicing modulator FR901464 is a potential agent for colorectal cancer in combination therapy
Oncotarget, 10(3), 352-367 (2019)
Meayamycin inhibits pre-messenger RNA splicing and exhibits picomolar activity against multidrug-resistant cells
Molecular Cancer Therapeutics, 8(8), 2308-2318 (2009)
Inhibition of splicing and nuclear retention of pre-mRNA by spliceostatin A in fission yeast
Biochemical and Biophysical Research Communications, 364(3), 573-577 (2007)
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