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SML3694

FR901464

≥95% (HPLC)

Synonym(s):

(2Z,4S)-4-(acetyloxy)-N-[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methyl-2,4-pentadien-1-yl]tetrahydro-2,5-dimethyl-2H-pyran-3-yl]-2-Pentenamide, FR 901464, WB 2663B

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About This Item

Empirical Formula (Hill Notation):
C27H41NO8
CAS Number:
146478-72-0
Molecular Weight:
507.62
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

shipped in

dry ice

storage temp.

−70°C

Biochem/physiol Actions

Inhibitor of pre-mRNA splicing; potent antitumor agent.

FR901464 is a potent anticancer agent isolated from the culture broth of the bacterium Pseudomonas sp. 2663. The compound binds to the splicing factor 3b complex and inhibits pre-mRNA splicing. FR901464 causes cell cycle arrest at the G1 and G2/M phases.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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