SML3711
DENSPM tetrahydrochloride
≥98% (HPLC)
Synonym(s):
BE 333 HCl, BENSpm HCl, DENSpm 4HCl, N1,N11-Diethylnorspermine tetrahydrochloride, N1,N11-bis(ethyl)norspermine tetrahydrochloride
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About This Item
Empirical Formula (Hill Notation):
C13H32N4· 4HCl
CAS Number:
Molecular Weight:
390.26
UNSPSC Code:
41121800
NACRES:
NA.21
MDL number:
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
DENSPM HCl is a nontoxic polyamine analog that enhances polyamine catabolism and production of hazardous hydrogen peroxide and N-acetyl-3-aminopropanal by inducing spermidine/spermine-N1-acetyl transferase (SSAT) expression. DENSPM HCl improves stem cell maintenance through reduced translation, exhibits slower proliferation rates in cancer cells, and induces autophagy. It shows greater antitumor activity and less associated toxicity in a human melanoma xenograft model.
Polyamine pathway inhibitor; potent inducer of spermidine/spermine N1-acetyltransferase
Disclaimer
Hygroscopic
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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