SML3717
C11-BODIPY581/591
≥95% (HPLC), fluorophore, powder
Synonym(s):
(T-4)-Difluoro[5-[[5-[(1E,3E)-4-phenyl-1,3-butadien-1-yl]-2H-pyrrol-2-ylidene-κN]methyl]-1H-pyrrole-2-undecanoato(2-)-κN1]-borate(1-), monohydrogen, BODIPY 581/591 C11, BP-C11, Borate(1-), (T-4)-difluoro[5-[[5-[(1E,3E)-4-phenyl-1,3-butadien-1-yl]-2H-pyrrol-2-ylidene-κN]methyl]-1H-pyrrole-2-undecanoato(2-)-κN1]-, hydrogen (1:1), C11 BODIPY(581/591), C11 BODIPY581/591, C11-BDP, C11-BODIPY, C11-BP
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About This Item
Empirical Formula (Hill Notation):
C30H35BF2N2O2
CAS Number:
Molecular Weight:
504.42
UNSPSC Code:
12352200
NACRES:
NA.21
Product Name
C11-BODIPY581/591, ≥95% (HPLC)
Quality Level
assay
≥95% (HPLC)
form
powder
storage condition
desiccated
color
brown to black
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
C11-BODIPY581/591 is an oxidation-sensitive fluorophore whose maximal ex/em wavelengths shift from 581/591 nm (red) to 500/510 (green) upon lipid peroxidation (LPO). The probe incorporates readily into lipid membranes and is useful for detecting and quantifying LPO of cell-free lipid preparations as well as in live cells by fluorometer (fluorimeter), fluorescence confocal microscopy (dual ex at 488 & 568 nm, detection by 530/30 nm and 590/30 nm bandpass filters) and flow cytometry (ex/em 484/510 for green, ex/em 581/610 for red signal).
Oxidation-sensitive fluorophore for detecting and quantifying lipid peroxidation (LPO) of cell-free lipid preparations as well as in live cells.
Disclaimer
Hygroscopic
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Ratio-fluorescence microscopy of lipid oxidation in living cells using C11-BODIPY(581/591)
Febs Letters, 453(3), 278-282 (1999)
Overexpression of ferroptosis defense enzyme Gpx4 retards motor neuron disease of SOD1G93A mice
Scientific Reports, 11(1), 12890-12890 (2021)
Delin Chen et al.
Nature communications, 12(1), 3644-3644 (2021-06-17)
Here, we identify iPLA2β as a critical regulator for p53-driven ferroptosis upon reactive oxygen species (ROS)-induced stress. The calcium-independent phospholipase iPLA2β is known to cleave acyl tails from the glycerol backbone of lipids and release oxidized fatty acids from phospholipids.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML3717-1MG | 04065269312437 |
| SML3717-5MG | 04065269312444 |