SML3721
PHA-680632
≥98% (HPLC)
Synonym(s):
N-(2,6-Diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)benzoyl]amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-(2,6-diethylphenyl)-N′-{3-[4-(4-methylpiperazino)benzamide)-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl}urea, PHA 680632, PHA680632
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About This Item
Empirical Formula (Hill Notation):
C28H35N7O2
CAS Number:
Molecular Weight:
501.62
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
N1(CCN(CC1)c2ccc(cc2)C(=O)Nc3n[nH]c4c3CN(C4)C(=O)Nc5c(cccc5CC)CC)C
InChI key
OBWNXGOQPLDDPS-UHFFFAOYSA-N
Biochem/physiol Actions
Potent and selective Aurora kinase inhibitor with anti-cancer efficacy in cultures and in animals in vivo.
PHA-680632 is a potent and selective Aurora kinase inhibitor (Aurora A/B/C IC50 = 27/135/120 nM; FGFR1 IC50 = 390 nM, 30- to 200-fold selectivity for Aurora A over 6 other kinases and IC50 >10 μM against 22 kinases) with antiproliferation activity in cancer cultures (IC50 ranges from 60 nM to 7.15 μM) and anti-tumor efficacy in mice and rats in vivo (15-60 mg/kg i.v. b.i.d. or 15-45 mg/kg i.p. t.i.d.)
PHA-680632 is a potent and selective Aurora kinase inhibitor (Aurora A/B/C IC50 = 27/135/120 nM; FGFR1 IC50 = 390 nM, 30- to 200-fold selectivity for Aurora A over 6 other kinases and IC50 >10 μM against 22 kinases) with antiproliferation activity in cancer cultures (IC50 ranges from 60 nM to 7.15 μM) and anti-tumor efficacy in mice and rats in vivo (15-60 mg/kg i.v. b.i.d. or 15-45 mg/kg i.p. t.i.d.)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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