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Merck
CN

SML3722

Dinaciclib

≥98% (HPLC)

Synonym(s):

(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol, 2-[(2S)-1-[3-Ethyl-7-[(1-oxidopyridin-1-ium-3-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]piperidin-2-yl]ethanol, MK 7965, MK-7965, MK7965, SCH 727965, SCH-727965, SCH727965

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About This Item

Empirical Formula (Hill Notation):
C21H28N6O2
CAS Number:
779353-01-4
Molecular Weight:
396.49
UNSPSC Code:
12352200
NACRES:
NA.21
MDL number:
MFCD16037702

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SMILES string

[n+]1(cc(ccc1)CNC2=CC(=Nc4[n]2ncc4CC)N3[C@@H](CCCC3)CCO)[O-]

InChI key

PIMQWRZWLQKKBJ-SFHVURJKSA-N

assay

≥98% (HPLC)

form

powder

color

, White to light brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor (CDK1/2/5/6/7/9 IC50 = 3/1/1/12/7/4 nM; Little or no inhibition of 41 other kinases at 10 μM) with potent antiproliferation activity in A2780 ovarian cancer cultures (IC50 = 4 nM by thymidine uptake assays). Dinaciclib exhibits potent anti-cancer efficacy in cultures (IC50 = 6-17 nM against 14 cancer cell lines) and in an A2780 tumor xenograft model in mice in vivo (8-48 mg/kg via daily i.p.).
Potent and selective cyclin-dependent kinase (CDK) inhibitor with potent anti-cancer efficacy in cultures and in mice in vivo.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000471406
0000471406
0000350766
0000350766
0000247247

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