SML3723
JNJ-26854165
≥98% (HPLC)
Synonym(s):
1-N-[2-(1H-Indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamine, JNJ 1, JNJ 26854165, N1-[2-(1H-Indol-3-yl)ethyl]-N4-4-pyridinyl-1,4-benzenediamine, Serdemetan
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About This Item
Empirical Formula (Hill Notation):
C21H20N4
CAS Number:
Molecular Weight:
328.41
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
[nH]1c2c(c(c1)CCNc3ccc(cc3)Nc4ccncc4)cccc2
InChI key
CEGSUKYESLWKJP-UHFFFAOYSA-N
Biochem/physiol Actions
Inhibitor of the E3 ligase human double minute-2 (HDM2); cholesterol transport inhibitor
JNJ-26854165 (serdemetan) is an inhibitor of the E3 ligase human double minute-2 (HDM2) that inhibits cell proliferation and induces apoptosis in models of acute myeloid and lymphoid leukemias, and solid tumors. Also JNJ-26854165 inhibits cholesterol transport. JNJ-26854165 appears to stimulate cholesterol regulatory genes, but simultaneously inhibits cholesterol transport.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Zih-Yin Lai et al.
International journal of molecular sciences, 22(16) (2021-08-28)
As the most common gene mutation found in cancers, p53 mutations are detected in up to 96% of high-grade serous ovarian carcinoma (HGSOC). Meanwhile, mutant p53 overexpression is known to drive oncogenic phenotypes in cancer patients and to sustain the
The novel anticancer agent JNJ-26854165 induces cell death through inhibition of cholesterol transport and degradation of ABCA1
Journal of Pharmacology and Experimental Therapeutics, 346(3), 381-392 (2013)
Liangshun You et al.
Oncotarget, 8(5), 7777-7790 (2016-12-22)
Chronic myeloid leukemia (CML) is a clonal malignant disease caused by the expression of BCR/ABL. MDM2 (human homolog of the murine double minute-2) inhibitors such as Nutlin-3 have been shown to induce apoptosis in a p53-dependent manner in CML cells
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML3723-5MG | 04065269311812 |
| SML3723-25MG | 04065269311805 |