SML3727
WIC1
≥98% (HPLC)
Synonym(s):
N-[4-(4-Ethyl-1-piperazinyl)phenyl]-2-oxo-2H-1-benzopyran-3-carboxamide, Wnt Inhibitor Compound 1
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About This Item
Empirical Formula (Hill Notation):
C22H23N3O3
CAS Number:
Molecular Weight:
377.44
UNSPSC Code:
12352200
NACRES:
NA.77
InChI key
YQXKWSNLAVFZJL-UHFFFAOYSA-N
SMILES string
O=C1OC2=C(C=C1C(NC3=CC=C(N4CCN(CC4)CC)C=C3)=O)C=CC=C2
assay
≥98% (HPLC)
form
powder
color
yellow to brown
solubility
DMSO:methanol (1:1): 2 mg/mL, clear (Warmed)
storage temp.
-10 to -25°C
Quality Level
Related Categories
Biochem/physiol Actions
Potent Wnt/β-catenin signaling inhibitor that reduces airway basal stem cell (ABSC) proliferation and induces ciliated cell differentiation.
WIC1 is a potent Wnt/β-catenin signaling inhibitor (IC50 = 10 nM against 24h 5 μM CHIR-induced BEAS2B TCF/LEF reporter activity) that reduces airway basal stem cell (ABSC) proliferation (92% reduction of 4d 2 μM CHIR-induced hABSC proliferation by 1 μM WIC1) and induces ciliated cell differentiation (by 1.9-fold on d14 with 100 nM WIC1; mABSCs under air-liquid interface (ALI) condition) by suppressing β-catenin Y489 phosphorylation (complete inhibition of 24h 5 μM CHIR-induced pY489 in BEAS2B by 1 μM WIC1) and TP63 expression (80% reduction of 9d 1 μM CHIR-induced TP63 in mABSC by 1 μM WIC1; 40% reduction of 48h 5 μM CHIR-induced TP63 in BEAS2B by 1 μM WIC1).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Cody J Aros et al.
Cell reports, 30(7), 2055-2064 (2020-02-23)
Mechanisms underpinning airway epithelial homeostatic maintenance and ways to prevent its dysregulation remain elusive. Herein, we identify that β-catenin phosphorylated at Y489 (p-β-cateninY489) emerges during human squamous lung cancer progression. This led us to develop a model of airway basal
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