SML3734
AO-159
≥98% (HPLC)
Synonym(s):
2,3,6,7-Tetramethyl 9-(4-methoxyphenyl)-1,4,8-trithiaspiro[4.5]deca-2,6,9-triene-2,3,6,7-tetracarboxylate, 9-(4-Methoxyphenyl)-1,4,8-trithiaspiro[4.5]deca-2,6,9-triene-2,3,6,7-tetracarboxylic acid 2,3,6,7-tetramethyl ester
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About This Item
Empirical Formula (Hill Notation):
C22H20O9S3
CAS Number:
Molecular Weight:
524.58
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
AO-159 is a cell penetrant and potent pan-HMT (pan- Histone Methyltransferase) inhibitor that effectively inhibit the enzymatic activity of both G9a and Suv39H1 enzymes. AO-159 potently reduces the levels of H3K9me1, H3K9me2, and H3K9me3 in COS7 cells. In inhibits the five histone H3K9 methylating enzymes Suv39H1, Suv39H2, SETDB1, G9a, and GLP at low micromolar concentrations.
Cell penetrant and potent pan-HMT (pan- Histone Methyltransferase) inhibitor that effectively inhibit the enzymatic activity of both G9a and Suv39H1 enzymes.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1? chromodomain in living cells
Cell Chemical Biology, 29(7), 1153-1161 (2022)
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