SML3747
IM1761092 hydrochloride
≥98% (HPLC)
Synonym(s):
IM 1092 hydrochloride, IM 1761092 hydrochloride, IM-1092 hydrochloride, IM-1761092 hydrochloride, IM1092 hydrochloride, N-1-(3-chloro-4-iodo)phenethylbiguanide hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C10H13ClIN5·HCl
CAS Number:
Molecular Weight:
402.06
UNSPSC Code:
12352200
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
room temp
SMILES string
ClC1=CC(CCNC(NC(N)=N)=N)=CC=C1I.Cl
InChI key
NSBWTYOKPDFWFE-UHFFFAOYSA-N
Biochem/physiol Actions
Biguanide-based mammalian respiratory complex I inhibitor that exhibits significantly higher potency than metformin and phenformin.
IM1761092 (IM1092) is a biguanide-based mammalian respiratory complex I inhibitor that reduces cellular oxygen consumption (IC50 = 3.6 μM post 6h treatment; HEPG2 C3A cells) and exhibits significantly higher potency than metformin and phenformin (by 10- to 2000-fold depending on the conditions) using bovine heart mitochondrial membrane preparations (IM1092/phenformin/metformin IC50 = 32 μM/3.8 mM/99 mM against active complex I, 4 μM/131 μM/33 mM against deactive complex I).
Disclaimer
Hygroscopic
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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