SML3748
TH10785
≥98% (HPLC)
别名:
N-Cyclohexyl-2-cyclopropyl-4-quinazolinamine, NN-Cyclohexyl-2-cyclopropylquinazolin-4-amine, TH 10785, TH-10785, V028-5832
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关于此项目
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
C1(N=C(C2CC2)N=C3NC4CCCCC4)=C3C=CC=C1
InChI key
ZQMGQZOHIDOPCQ-UHFFFAOYSA-N
Biochem/physiol Actions
8-oxoG DNA glycosylase OGG1 activator that induced β,δ-lyase activity for polynucleotide kinase phosphatase (PNKP1)-dependent base excision repair (BER).
TH10785 is an 8-oxoguanine (8-oxoG) DNA glycosylase 1 (OGG1) activator that interats with OGG1 via Phe319 and Gly42, causing increased OGG1 recruitment to cellular oxidative DNA damage sites (by 1.37-fold post 20 sec 1 µM treatment; U2OS). TH10785-activated OGG1 recognizes not only 8-oxoG, but also apurinic/apyrimidinic (AP, abasic) sites with a higher efficiency due to a newly induced β,δ-lyase enzymatic activity that generates base excision repair (BER) intermediates that require polynucleotide kinase phosphatase (PNKP1) instead of apurinic endonuclease 1 (APE1) for completing the repair.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable