Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C14H14FNO2S
CAS Number:
Molecular Weight:
279.33
NACRES:
NA.28
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Orally active dopamine receptor D1-selective postive allosteric modulator (PAM) in vitro and in vivo.
UCM-1306 is an orally active dopamine receptor D1-selective postive allosteric modulator (PAM) void of D1 agonist activity. UCM-1306 potentiates dopamine (DA)-induced cAMP in the SK-N-MC neuroblastoma cell line with endogenous D1R (EC50/Emax = 60 nM/45% with [DA] = EC70; Emax = 55% with [DA] = 10 μM), but not D5R, by modulating DA affinity for the receptor, while displaying low binding competition against orthosteric ligands. UCM-1306 augments cocaine (20 mg/kg s.c.)-induced locomotion (1 mg/kg i.p.) and enhances L-DOPA (100-400 mg/kg i.p.) recovery of decreased locomotor activity in reserpinized (2.5 mg/kg s.c.) mice in vivo (30 mg/kg p.o.).
UCM-1306 is an orally active dopamine receptor D1-selective postive allosteric modulator (PAM) void of D1 agonist activity. UCM-1306 potentiates dopamine (DA)-induced cAMP in the SK-N-MC neuroblastoma cell line with endogenous D1R (EC50/Emax = 60 nM/45% with [DA] = EC70; Emax = 55% with [DA] = 10 μM), but not D5R, by modulating DA affinity for the receptor, while displaying low binding competition against orthosteric ligands. UCM-1306 augments cocaine (20 mg/kg s.c.)-induced locomotion (1 mg/kg i.p.) and enhances L-DOPA (100-400 mg/kg i.p.) recovery of decreased locomotor activity in reserpinized (2.5 mg/kg s.c.) mice in vivo (30 mg/kg p.o.).
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service