SML3751
HS-84
≥98% (HPLC), Tau protein luminescent probe, powder
Synonym(s):
5,5′′′′-dicarboxy-[2,2′:5′,2′′:5′′,2′′′:5′′′,2′′′′-Quinquethiophene]-3′,4′′′-diacetic acid sodium salt
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About This Item
Empirical Formula (Hill Notation):
C26H12Na4O8S5
CAS Number:
Molecular Weight:
704.65
UNSPSC Code:
12352200
NACRES:
NA.21
Product Name
HS-84, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
, Light orange to very dark red
solubility
H2O: 2 mg/mL, clear
storage temp.
room temp
Quality Level
Related Categories
Biochem/physiol Actions
Brain blood barrier penetrant luminescent probe that binds to binds to fibrillary tau protein
HS-84, a luminescent conjugated oligothiophene, is a brain blood barrier penetrant luminescent probe that binds to binds to fibrillary tau protein. HS-84 single photon excitation maximum is ~ 430 nm, and emission maximum are ~ 512, 547 nm. It does not fade within hours. HS-84 is a suitable probe for longitudinal in vivo detection of neurofibrillary tangles using multiphoton microscopy in the Tg mouse brain.
Disclaimer
Hygroscopic
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Deciphering the Electronic Transitions of Thiophene-Based Donor-Acceptor-Donor Pentameric Ligands Utilized for Multimodal Fluorescence Microscopy of Protein Aggregates
ChemPhysChem, 22(3), 323-335 (2021)
In vivo detection of tau fibrils and amyloid ? aggregates with luminescent conjugated oligothiophenes and multiphoton microscopy
Acta Neuropathologica Communications, 7(1), 171-171 (2019)
Pentameric thiophene-based ligands that spectrally discriminate amyloid-? and tau aggregates display distinct solvatochromism and viscosity-induced spectral shifts
Chemistry (Weinheim An Der Bergstrasse, Germany), 20(39), 12537-12543 (2014)
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