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Merck
CN

SML3754

SRT2104

≥98% (HPLC)

Synonym(s):

4-Methyl-N-(2-(3-(morpholinomethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-(pyridin-3-yl)thiazole-5-carboxamide, 4-Methyl-N-(2-{3-[(morpholin-4-yl)methyl]imidazo[2,1-b][1,3]thiazol-6-yl}phenyl)-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide, GSK 2245840B, GSK-2245840B, GSK2245840B, SRT 2104, SRT-2104

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About This Item

Empirical Formula (Hill Notation):
C26H24N6O2S2
CAS Number:
1093403-33-8
Molecular Weight:
516.64
UNSPSC Code:
12352200
NACRES:
NA.21
MDL number:
MFCD22572733

Key Documents

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SMILES string

[s]1c(nc(c1C(=O)Nc3c(cccc3)c4nc5[s]cc([n]5c4)CN6CCOCC6)C)c2cnccc2

InChI key

LAMQVIQMVKWXOC-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

Quality Level

100

Biochem/physiol Actions

Orally active sirtuin 1 (Sirt1) activator in vitro and in vivo.
SRT2104 is an orally active, potent and highly selective activator of the NAD+-dependent deacetylase sirtuin Sirt1 (EC1.5 = 450 nM) with in vivo efficacy in various animal models, including age-related bone/muscle loss (100 mg/kg/d via chow to mice), HD (0.5% in chow to mice), TNF-induced optic nerve degeneration (2-200 pmol via intravitreal injection to rats).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000303357
0000303359
0000303357
0000303359
0000286413

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SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass
Aging Cell, 13(5), 787-796 (2014)
Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence
COPD, 17(4), 444-451 (2020)
The SIRT1 activator SRT2104 promotes BMP9-induced osteogenic and angiogenic differentiation in mesenchymal stem cells
Mechanisms of Ageing and Development, 207, 111724-111724 (2022)
Axonal protection by a small molecule SIRT1 activator, SRT2104, with alteration of autophagy in TNF-induced optic nerve degeneration
Japanese Journal of Ophthalmology, 64(3), 298-303 (2020)
Sirtuin 1 activator SRT2104 protects Huntington's disease mice
Annals of Clinical and Translational Neurology, 1(12), 1047-1052 (2014)
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