SML3758
Trpvicin
≥98% (HPLC)
Synonym(s):
N-(5-(2-(2-Cyanopropan-2-yl)pyridin-4-yl)-4-(trifluoromethyl)thiazol-2-yl)-4,6-dimethoxypyrimidine-5-carboxamide, N-[5-[2-(1-Cyano-1-methylethyl)-4-pyridinyl]-4-(trifluoromethyl)-2-thiazolyl]-4,6-dimethoxy-5-pyrimidinecarboxamide
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About This Item
Empirical Formula (Hill Notation):
C20H17F3N6O3S
CAS Number:
Molecular Weight:
478.45
NACRES:
NA.21
UNSPSC Code:
12352200
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
Sub-type selective and potent inhibitor of TRPV3
Trpvicin is a sub-type selective and potent inhibitor of TRPV3. Trpvicin shows efficacy in the inhibition of itch and hair loss in mouse models. It appears that Trpvicin stabilizes TRPV3 channel in its a closed state.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Structural basis of TRPV3 inhibition by an antagonist
Nature Chemical Biology, 19(1), 81-90 (2023)
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