SML3759
MU1742
≥95% (HPLC)
Synonym(s):
4-(1-((4-Fluoro-1-methylpiperidin-4-yl)methyl)-4-(5-fluoropyridin-2-yl)-1H-imidazol-5-yl)-1H-pyrrolo[2,3-b]pyridine, MU 1742, MU-1742
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About This Item
Empirical Formula (Hill Notation):
C22H22F2N6
Molecular Weight:
408.45
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
powder
Quality Segment
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
FC5(CCN(CC5)C)C[n]1cnc(c1c3c4c([nH]cc4)ncc3)c2ncc(cc2)F
InChI key
SWOIFXHMBKFCRM-UHFFFAOYSA-N
Biochem/physiol Actions
MU1742 is an orally active, potent and selective casein kinase 1 inhibitor (CK1α/δ/ε IC50 = 7/6/28 nM; p38α IC50 >3 μM) with high kinome-wide selectivity. MU1742 inhibits CLL19-induced chemotaxis (IC50 = 200 nM; MEC1 cells) and CK1δ/ε-dependent DVL3 phosphorylation (IC50 = 200 nM post 18h treatment; HL60 cells) in cultures and in lung tissue in mice in vivo (5h post 100 mg/kg p.o. using HCl salt form).
Orally active, potent and selective casein kinase 1 (CK1, CKI) inhibitor in vitro and in vivo.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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