SML3761
BRD7586
≥98% (HPLC)
Synonym(s):
3-[(4-Chlorophenyl)sulfonyl]-N-[4-(4-pyridinyl)-2-thiazolyl]propanamide
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About This Item
Empirical Formula (Hill Notation):
C17H14ClN3O3S2
Molecular Weight:
407.89
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
[S](=O)(=O)(CCC(=O)Nc2[s]cc(n2)c3ccncc3)c1ccc(cc1)Cl
InChI
1S/C17H14ClN3O3S2/c18-13-1-3-14(4-2-13)26(23,24)10-7-16(22)21-17-20-15(11-25-17)12-5-8-19-9-6-12/h1-6,8-9,11H,7,10H2,(H,20,21,22)
InChI key
MLSIIIMAQNQEOV-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Related Categories
Biochem/physiol Actions
BRD7586 is a cell-permeable, and potent anti-CRISPR agent. BRD7586is a potent and selective inhibitor of SpCas9. It potently inhibits SpCas9 in both HEK293T and U2OS.eGFP.PEST cells without altering its expression, or induction of cytotoxicity. BRD7586 enhanced the specificity of SpCas9. BRD7586 inhibits genome editing at diverse endogenous loci. It is twofold more potent than BRD0539.
Cell-permeable, and potent anti-CRISPR agent; potent and selective inhibitor of SpCas9
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules
Nature Cell Biology, 24(12), 1766-1775 (2022)
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