SML3761
BRD7586
≥98% (HPLC)
别名:
3-[(4-Chlorophenyl)sulfonyl]-N-[4-(4-pyridinyl)-2-thiazolyl]propanamide
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关于此项目
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
[S](=O)(=O)(CCC(=O)Nc2[s]cc(n2)c3ccncc3)c1ccc(cc1)Cl
InChI
1S/C17H14ClN3O3S2/c18-13-1-3-14(4-2-13)26(23,24)10-7-16(22)21-17-20-15(11-25-17)12-5-8-19-9-6-12/h1-6,8-9,11H,7,10H2,(H,20,21,22)
InChI key
MLSIIIMAQNQEOV-UHFFFAOYSA-N
Biochem/physiol Actions
BRD7586 is a cell-permeable, and potent anti-CRISPR agent. BRD7586is a potent and selective inhibitor of SpCas9. It potently inhibits SpCas9 in both HEK293T and U2OS.eGFP.PEST cells without altering its expression, or induction of cytotoxicity. BRD7586 enhanced the specificity of SpCas9. BRD7586 inhibits genome editing at diverse endogenous loci. It is twofold more potent than BRD0539.
Cell-permeable, and potent anti-CRISPR agent; potent and selective inhibitor of SpCas9
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable