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Merck
CN

SML3775

Desthiobiotin-Phenol

≥98% (HPLC), peroxidase sensitive probe, powder

Synonym(s):

(4R,5S)-N-[2-(4-Hydroxyphenyl)ethyl]-5-methyl-2-oxo-4-imidazolidinehexanamide, DBP, Desthiobiotin-Tyramide, N-(4-Hydroxyphenethyl)-6-((4R,5S)-5-methyl-2-oxoimidazolidin-4-yl)hexanamide, d-Desthiobiotin-Phenol

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About This Item

Empirical Formula (Hill Notation):
C18H27N3O3
CAS Number:
Molecular Weight:
333.43
UNSPSC Code:
12352200
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
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Product Name

Desthiobiotin-Phenol, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

A peroxidase-sensitive desthiobiotin-phenol (DBP) probe that offers more efficient recovery of DBP-labeled peptides from streptavidin beads and stronger mass spectrometry intensity of modified membrane proteins and achieves greater sensitivity for tyrosine residues detection. DBP shows a similar reactivity to the protein when it is converted to the phenoxyl radical state as biotin-phenol/biotin-tyramide (BP) in ascorbate peroxidase (APEX) proximity labeling. DBP exhibits reduced affinity to streptavidin and does not suffer from sulfur oxidation issue during the radical generation.
APEX (ascorbate peroxidase) proximity tyrosine site label, a sulfur-free Biotin-Tyramide analog that can be displaced competitively by biotin


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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