Skip to Content
Merck
CN

SML3779

Methotrexate disodium salt

≥98% (HPLC)

Synonym(s):

Amethopterin sodium, N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid disodium salt, Sodium methotrexate

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C20H20N8Na2O5
CAS Number:
7413-34-5
Molecular Weight:
498.40
UNSPSC Code:
12352200
NACRES:
NA.21
MDL number:
MFCD00274560

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

SMILES string

[Na].[Na].N([C@@H](CCC(=O)O)C(=O)O)C(=O)c1ccc(cc1)N(Cc2nc3c(nc(nc3N)N)nc2)C

InChI key

HQRCOVOSZPGUCA-GXKRWWSZSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to brown

solubility

H2O: 2 mg/mL, clear

storage temp.

-10 to -25°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Folic acid antagonist that is used as an antineoplastic and antirheumatic drug
Methotrexate disodium salt is a potent is a folic acid antagonist that is used as an antineoplastic and antirheumatic drug. Methotrexate disodium salt is a potent inhibitor of dihydrofolate reductase.

Disclaimer

Hygroscopic

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000487095
0000487095
0000465549
0000467097
0000465549

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Molecular basis for pharmacokinetics and pharmacodynamics of methotrexate in rheumatoid arthritis therapy
Drug Metabolism and Pharmacokinetics, 29(1), 12-19 (2014)
The effects of drug transporters on the efficacy of methotrexate in the treatment of rheumatoid arthritis
Life Sciences, 268, 118907-118907 (2021)
Marrubium alysson L. Ameliorated Methotrexate-Induced Testicular Damage in Mice through Regulation of Apoptosis and miRNA-29a Expression: LC-MS/MS Metabolic Profiling.
Plants (Basel, Switzerland), 11(17), 2309-2309 (2022)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service