SML3785
Levonadifloxacin
≥98% (HPLC)
Synonym(s):
(5S)-9-Fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid, (S)-(-)-Nadifloxacin, (S)-9-Fluoro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid, WCK 771
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About This Item
Empirical Formula (Hill Notation):
C19H21FN2O4
CAS Number:
Molecular Weight:
360.38
UNSPSC Code:
51111800
NACRES:
NA.21
MDL number:
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Related Categories
Biochem/physiol Actions
Levonadifloxacin is a potent benzoquinolizine fluoroquinolone antibiotic that is affective against Gram-positive and Gram-negative bacteria, including methicillin- and quinolone-resistant Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, and Moraxella catarrhalis and atypical pathogens. It appears that Levonadifloxacin targets staphylococcal DNA gyrase, unlike other quinolones, which primarily inhibit DNA topoisomerase IV.
Potent benzoquinolizine fluoroquinolone antibiotic that is affective against Gram-positive and Gram-negative bacteria
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Structural Characterization of the Millennial Antibacterial (Fluoro)Quinolones-Shaping the Fifth Generation
Pharmaceutics, 13(8), 1289-1289 (2021)
In vitro bactericidal activity of levonadifloxacin (WCK 771) against methicillin- and quinolone-resistant Staphylococcus aureus biofilms
Journal of Medical Microbiology, 68(8), 1129-1136 (2019)
Levonadifloxacin, a Novel Broad-Spectrum Anti-MRSA Benzoquinolizine Quinolone Agent: Review of Current Evidence
Drug design, development and therapy, 13, 4351-4365 (2019)
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