SML3789
MS67
≥98% (HPLC)
Synonym(s):
N-(2′-fluoro-5′-((2-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3dimethyl-1-oxobutan-2-yl)amino)-2-oxoethyl)carbamoyl)-4-((3S,5R)-3,4,5-trimethylpiperazin-1-yl)-[1,1′-biphenyl]-3-yl)-6-oxo 4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
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About This Item
Empirical Formula (Hill Notation):
C52H59F4N9O7S
CAS Number:
Molecular Weight:
1030.14
NACRES:
NA.21
UNSPSC Code:
12352200
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Cell penetrant, potent and selective WD40 repeat domain protein 5 (WDR5) degrader
MS67 is a cell penetrant, potent and selective WD40 repeat domain protein 5 (WDR5) degrader that effectively and selectively degrades WDR5 in human MLL-r AML and PDAC cells.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models
Science Translational Medicine, 13(613), eabj1578-eabj1578 (2021)
Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation.
Wesley L Cai et al.
eLife, 11 (2022-09-01)
Metastatic breast cancer remains a major cause of cancer-related deaths in women, and there are few effective therapies against this advanced disease. Emerging evidence suggests that key steps of tumor progression and metastasis are controlled by reversible epigenetic mechanisms. Using
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML3789-5MG | 04065270170385 |
| SML3789-25MG | 04065270170378 |