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Merck
CN

SML3790

Sigma-Aldrich

MS67N

≥98% (HPLC)

Synonym(s):

N-(2′-Fluoro-5′-((2-(((S)-1-((2R,4S)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethyl)carbamoyl)-4-((3S,5R)-3,4,5-trimethylpiperazin-1-yl)-[1,1′-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C52H59F4N9O7S
CAS Number:
Molecular Weight:
1030.14
UNSPSC Code:
12352200
NACRES:
NA.21
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Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

MS67N is a diastereoisomer of WDR5 degrader MS67 that serves as negative control.
Negative control for WDR5 degrader MS67

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models
Science Translational Medicine, 13(613) (2021)
Wesley L Cai et al.
eLife, 11 (2022-09-01)
Metastatic breast cancer remains a major cause of cancer-related deaths in women, and there are few effective therapies against this advanced disease. Emerging evidence suggests that key steps of tumor progression and metastasis are controlled by reversible epigenetic mechanisms. Using

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