Skip to Content

Key Documents

View All Documentation

SML3793

MS4322

≥95% (HPLC)

Synonym(s):

N-((S)-3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-((1-((S)-19-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidine-1-carbonyl)-20,20-dimethyl-17-oxo-3,6,9,12,15-pentaoxa-18-azahenicosanoyl)azetidin-3-yl)amino)pyrimidine-4-carboxamide

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C55H76N10O12S
CAS Number:
2375432-47-4
Molecular Weight:
1101.32
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
powder
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Segment

100

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

Potent, cell-permeable, highly selective and yet a slow PRMT5 degrader.

MS4322 is a potent, cell-permeable, highly selective and yet a slow PRMT5 (protein arginine methyltransferase 5) degrader. It comprises of PRMT5 inhibitor EPZ015666 linked to a von Hippel-Lindau (VHL) E3 ligase ligand (S,R,S)-AHPC-Me (VHL-2). MS4322 reduces PRMT5 protein levels in a concentration-, time-, VHL- and proteasome-dependent manner. Inhibits PRMT5 activity (IC50 = 18 nM) and reduces arginine symmetric dimethylation (SDMA) levels. MS4322 displays good plasma exposure in a mouse PK study and in vivo availability.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library