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Merck
CN

SML3795

Sigma-Aldrich

BAY-3827

≥98% (HPLC), AMPK (AMP-activated protein kinase) inhibitor, powder

Synonym(s):

AMPK inhibitor BAY3827, BAY 3827, N-[5-(3,5-Dicyano-1,2,6-trimethyl-1,4-dihydropyridin-4-yl)-6-fluoro-7-methyl-1H-indazol-3-yl]-2-ethylbenzamide, N-[5-(3,5-Dicyano-1,4-dihydro-1,2,6-trimethyl-4-pyridinyl)-6-fluoro-7-methyl-1H-indazol-3-yl]-2-ethylbenzamide

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About This Item

Empirical Formula (Hill Notation):
C27H25FN6O
CAS Number:
2377576-35-5
Molecular Weight:
468.53
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

BAY-3827, ≥98% (HPLC)

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

N#CC1=C(N(C(C)=C(C#N)C1C2=CC3=C(NN=C3NC(C4=C(C=CC=C4)CC)=O)C(C)=C2F)C)C

InChI key

OZFFKOSQNBBYCA-UHFFFAOYSA-N

Biochem/physiol Actions

BAY-3827 is a selective and potent inhibitor of AMPK (AMP-activated protein kinase) and RSK1 (ribosomal 6 kinase 1) that exhibit strong anti-proliferative activity in androgen-dependent prostate cancer cell lines. BAY-3827 strongly down-regulates lipase E (LIPE), cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B), serine-threonine kinase AKT3 and carnitine palmitoyl-transferase 1 (CPT1) family expression levels and impairs lipid flux.
Selective and potent inhibitor of AMPK and RSK1 that exhibit strong anti-proliferative activity in androgen-dependent prostate cancer cell lines

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000482738
0000440008
0000440008
0000392827
0000392827

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