SML3798
Iptakalim hydrochloride
≥98% (HPLC)
Synonym(s):
2,3-dimethyl-N-(1-methylethyl)-2-butanamine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C9H21N·HCl
CAS Number:
Molecular Weight:
179.73
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
[Cl-].[N+H2](C(C(C)C)(C)C)C(C)C
InChI
1S/C9H21N.ClH/c1-7(2)9(5,6)10-8(3)4;/h7-8,10H,1-6H3;1H
InChI key
RXNJQAYLNOXYKW-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Brain blood barrier penetrant ATP-sensitive potassium channel (KATP) opener that attenuates hypoxia-induced pulmonary arterial hypertension in rats; K(ir) 6.1/SUR2B activator.
Iptakalim hydrochloride is a brain blood barrier penetrant ATP-sensitive potassium channel (KATP) opener that attenuates hypoxia-induced pulmonary arterial hypertension in rats. Iptakalim hydrochloride is a selective antagonist of α4β2-containing nicotinic acetylcholine receptor (nAChR).
Iptakalim hydrochloride is a brain blood barrier penetrant ATP-sensitive potassium channel (KATP) opener that attenuates hypoxia-induced pulmonary arterial hypertension in rats. Iptakalim hydrochloride is a selective antagonist of α4β2-containing nicotinic acetylcholine receptor (nAChR).
Disclaimer
Hygroscopic
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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A new ATP-sensitive potassium channel opener protects the kidney from hypertensive damage in spontaneously hypertensive rats
Journal of Pharmacology and Experimental Therapeutics, 315(2), 501-509 (2005)
Iptakalim: A novel multi-utility potassium channel opener
Journal of Pharmacology & Pharmacotherapeutics, 3(1), 12-14 (2012)
Iptakalim as a human nicotinic acetylcholine receptor antagonist
Journal of Pharmacology and Experimental Therapeutics, 316(2), 914-925 (2006)
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