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SML3811

Hygromycin A

Name: Hygromycin A
Brand: SIGMA

≥98% (HPLC), Antibiotic, powder

Synonym(s):

Totomycin, 5-Deoxy-5-[[(2E)-3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-propen-1-yl]amino]-1,2-O-methylene-D-neo-inositol, Homomycin, Hygromycin

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₂₉NO₁₂

CAS Number:

6379-56-2

Molecular Weight:

511.48

UNSPSC Code:

51111800

NACRES:

NA.21

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Product Name

Hygromycin A, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

O[C@H]1[C@]2([H])[C@@]([C@@H]([C@@H]([C@@H]1O)NC(/C(C)=C/C3=CC=C(C(O)=C3)O[C@@H]4O[C@@H]([C@H]([C@@H]4O)O)C(C)=O)=O)O)([H])OCO2

InChI

1S/C23H29NO12/c1-8(22(32)24-13-14(27)16(29)21-20(15(13)28)33-7-34-21)5-10-3-4-12(11(26)6-10)35-23-18(31)17(30)19(36-23)9(2)25/h3-6,13-21,23,26-31H,7H2,1-2H3,(H,24,32)/b8-5+/t13-,14+,15-,16-,17+,18+,19-,20+,21-,23-/m1/s1

InChI key

YQYJSBFKSSDGFO-IIHALWDASA-N

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Biochem/physiol Actions

An orally available antibiotic; selectively taken up by nucleoside transporter specific to spirochete bacteria including Borreliella burgdorferi

Hygromycin A is an orally available antibiotic produced by Streptomyces hygroscopicus that targets the ribosomal 23S rRNA. Hygromycin A is selectively taken up by nucleoside transporter specific to spirochete bacteria including Borreliella burgdorferi, which causes Lyme disease. It clears B. burgdorferi infection in mice with lesser disruption of micron=biome than clinical antibiotics.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Perturbation of ribosomal subunit dynamics by inhibitors of tRNA translocation

RNA, 27(9), 981-990 (2021)

A selective antibiotic for Lyme disease

Cell, 184(21), 5405-5418 (2021)

Global Trade Item Number

SKU	GTIN
SML3811-5MG	04065270291752
SML3811-25MG	04065270291745

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