Skip to Content
Merck
CN

SML3812

Asunaprevir

≥98% (HPLC)

Synonym(s):

Asunaprevir, BMS650032, 3-Methyl-N-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-valyl-(4R)-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-vinylcyclopropyl}-L-prolinamide, ASV, BMS 650032, BMS-650032

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C35H46ClN5O9S
CAS Number:
630420-16-5
Molecular Weight:
748.29
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
MFCD27987900

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Asunaprevir, ≥98% (HPLC)

InChI

1S/C35H46ClN5O9S/c1-9-19-16-35(19,31(44)40-51(46,47)22-11-12-22)39-28(42)25-15-21(49-29-24-14-20(36)10-13-23(24)26(48-8)17-37-29)18-41(25)30(43)27(33(2,3)4)38-32(45)50-34(5,6)7/h9-10,13-14,17,19,21-22,25,27H,1,11-12,15-16,18H2,2-8H3,(H,38,45)(H

SMILES string

CC(C)(C)[C@@H](C(=O)N1C[C@@H](C[C@H]1C(=O)N[C@@]2(C[C@H]2C=C)C(=O)NS(=O)(=O)C3CC3)OC4=NC=C(C5=C4C=C(C=C5)Cl)OC)NC(=O)OC(C)(C)C

InChI key

XRWSZZJLZRKHHD-QGQNBIQGSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Quality Level

100

Looking for similar products? Visit Product Comparison Guide

Related Categories

Biochem/physiol Actions

Asunaprevir (ASV; BMS-650032) is an orally active, potent and selective hepatitis C virus (HCV) NS3 protease inhibitor (HCV NS3/4A IC50 = 0.7 nM; GBV-B NS3/4A IC50 = 21 µM, IC50 >5 µM using 11 human serine and cysteine proteases) that targets the NS3/4A protease complex with high affinity (Ki = 0.4 and 0.24 nM, using genotypes 1a (H77) and 1b (J4L6S), respectively). ASV inhibits HCV replication in cultures (IC50 = 1-4 nM/replicon genotypes 1 & 4, 67 nM-1.162 µM/replicon genotypes 2 & 3, >12 μM against a panel of other RNA viruses).

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H373

Hazard Classifications

STOT RE 2

target_organs

Liver

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000505302
0000505302
0000481863
0000481870
0000302946

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032)
Antimicrobial Agents and Chemotherapy, 56(10), 5387-5396 (2012)
Combinations of lambda interferon with direct-acting antiviral agents are highly efficient in suppressing hepatitis C virus replication
Antimicrobial Agents and Chemotherapy, 57(3), 1312-1322 (2013)
Combination treatment with hepatitis C virus protease and NS5A inhibitors is effective against recombinant genotype 1a, 2a, and 3a viruses
Antimicrobial Agents and Chemotherapy, 57(3), 1291-1303 (2013)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service