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Merck
CN

SML3818

YL-939

≥98% (HPLC)

Synonym(s):

8-(3,6-dihydro-2H-pyran-4-yl)-2-phenyl-6-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine

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About This Item

Empirical Formula (Hill Notation):
C25H26N6O
CAS Number:
Molecular Weight:
426.51
MDL number:
NACRES:
NA.28
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
Technical Service
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Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

room temp

SMILES string

C(N=C1C2=CCOCC2)(C3=CN(N=C3)C4CCNCC4)=CN5C1=NC(C6=CC=CC=C6)=C5

Biochem/physiol Actions

Cell penetrant, potent and selective ferroptosis inhibitor that targets prohibitin 2 (PHB2).
YL-939 is a cell penetrant, potent and selective ferroptosis inhibitor. YL-939 binds directly to prohibitin 2 (PHB2) hence promoting the expression of the iron storage protein ferritin thus reducing the iron content, thereby decreasing the susceptibility to ferroptosis. YL-939 effectively protects cells from ferroptosis.


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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Global Trade Item Number

SKUGTIN
SML3818-25MG04065270303042
SML3818-5MG04065270303059