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Merck
CN

SML3819

Sigma-Aldrich

UNC-CA157

≥98% (HPLC)

Synonym(s):

4-((3,4,5-Trimethoxyphenyl)amino)quinoline-7-carbonitrile, 4-[(3,4,5-Trimethoxyphenyl)amino]-7-quinolinecarbonitrile

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About This Item

Empirical Formula (Hill Notation):
C19H17N3O3
CAS Number:
Molecular Weight:
335.36
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

Cell penetrant, selective and potent inhibitor of archetypal UbiB protein COQ8.
UNC-CA157 is a cell penetrant, selective and potent inhibitor of COQ8 the member of archetypal UbiB family of atypical kinases (protein kinase-like (PKL) family). UNC-CA157 inhibits CoQ production in COQ8BKO cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Small-molecule inhibition of the archetypal UbiB protein COQ8
Nature Chemical Biology, 19(2), 230-238 (2023)
Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase
ChemMedChem, 13(1), 48-66 (2018)

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