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Merck
CN

SML3819

UNC-CA157

≥98% (HPLC)

Synonym(s):

4-((3,4,5-Trimethoxyphenyl)amino)quinoline-7-carbonitrile, 4-[(3,4,5-Trimethoxyphenyl)amino]-7-quinolinecarbonitrile

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About This Item

Empirical Formula (Hill Notation):
C19H17N3O3
CAS Number:
Molecular Weight:
335.36
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
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Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

Cell penetrant, selective and potent inhibitor of archetypal UbiB protein COQ8.
UNC-CA157 is a cell penetrant, selective and potent inhibitor of COQ8 the member of archetypal UbiB family of atypical kinases (protein kinase-like (PKL) family). UNC-CA157 inhibits CoQ production in COQ8BKO cells.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Small-molecule inhibition of the archetypal UbiB protein COQ8
Nature Chemical Biology, 19(2), 230-238 (2023)
Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase
ChemMedChem, 13(1), 48-66 (2018)

Global Trade Item Number

SKUGTIN
SML3819-25MG04065270303196
SML3819-5MG04065270303202

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